Last updated on 2025-08-12 13:48:25 CEST.
| Flavor | Version | Tinstall | Tcheck | Ttotal | Status | Flags |
|---|---|---|---|---|---|---|
| r-devel-linux-x86_64-debian-clang | 2.7.0 | 41.23 | 731.12 | 772.35 | ERROR | |
| r-devel-linux-x86_64-debian-gcc | 2.7.0 | 29.13 | 485.59 | 514.72 | OK | |
| r-devel-linux-x86_64-fedora-clang | 2.7.0 | 1151.46 | ERROR | |||
| r-devel-linux-x86_64-fedora-gcc | 2.7.0 | 1187.40 | OK | |||
| r-devel-windows-x86_64 | 2.7.0 | 55.00 | 781.00 | 836.00 | OK | |
| r-patched-linux-x86_64 | 2.7.0 | 49.53 | 715.83 | 765.36 | OK | |
| r-release-linux-x86_64 | 2.7.0 | 42.43 | 695.80 | 738.23 | ERROR | |
| r-release-macos-arm64 | 2.7.0 | 293.00 | OK | |||
| r-release-macos-x86_64 | 2.7.0 | 556.00 | OK | |||
| r-release-windows-x86_64 | 2.7.0 | 57.00 | 782.00 | 839.00 | OK | |
| r-oldrel-macos-arm64 | 2.7.0 | 322.00 | NOTE | |||
| r-oldrel-macos-x86_64 | 2.7.0 | 566.00 | NOTE | |||
| r-oldrel-windows-x86_64 | 2.7.0 | 73.00 | 1036.00 | 1109.00 | NOTE |
ATLAS donttest MKL noLD valgrind
Version: 2.7.0
Check: examples
Result: ERROR
Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: solve_dermal_pbtk
> ### Title: Solve_dermal_PBTK
> ### Aliases: solve_dermal_pbtk
> ### Keywords: Solve
>
> ### ** Examples
>
>
> # Dermal exposure to default dose
> out <- solve_dermal_pbtk(chem.name="bisphenola")
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
Vvehicle not specified, so set to 0.1 L.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
The initial.dose is automatically set to 1mg/kg.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment, :
Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Funbound.plasma recalculated with adjustment. Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species, :
Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
None of the monitored components undergo unit conversions (i.e. conversion factor of 1).
AUC is area under the plasma concentration curve in uM*days units with Rblood2plasma = 0.77.
The model outputs are provided in the following units:
umol: Avehicle, Aplasma, Ain, Aexhaled, Atubules, Ametabolized
uM: Cgut, Cliver, Cven, Clung, Cart, Crest, Ckidney, Cplasma, Cskin_exposed, Cskin_unexposed, Cvehicle
uM*days: AUC
> # Dermal exposure to 20 mg/L in 0.01 L of octanol with wash-off after 8 hours
> # Since skin permeability happens quickly for bisphenol A, let's only look at 3 days.
> dose.conc <- 2 #mg/L
> Vvehicle <- 0.01 #L
> initial.dose <- dose.conc*Vvehicle
> out <- solve_dermal_pbtk(chem.name="bisphenola", initial.dose=initial.dose,
+ input.units="mg", Vvehicle=0.01,
+ Kskin2vehicle="octanol", dose.duration=8,
+ dose.duration.units="hr", days=3)
Warning in solve_dermal_pbtk(chem.name = "bisphenola", initial.dose = initial.dose, :
If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola", initial.dose = initial.dose, :
Washoff occurs automatically if dose.duration is used.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment, :
Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Funbound.plasma recalculated with adjustment. Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species, :
Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
DLSODA- At T (=R1), too much accuracy requested
for precision of machine.. See TOLSF (=R2)
In above message, R1 = 9.99855e-06, R2 = nan
Warning in lsoda(y, times, func, parms, ...) :
Excessive precision requested. scale up `rtol' and `atol' e.g by the factor 10
Warning in lsoda(y, times, func, parms, ...) :
Returning early. Results are accurate, as far as they go
Error in (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
Some of the requested variables to monitor (monitor.vars) are not in
the columns of the deSolve output object. These variables should
belong to either the states or outputs of the model.
Calls: solve_dermal_pbtk -> do.call -> <Anonymous>
Execution halted
Examples with CPU (user + system) or elapsed time > 5s
user system elapsed
parameterize_steadystate 6.622 0.039 9.867
solve_1tri_pbtk 6.540 0.036 8.694
solve_1comp 5.962 0.074 8.744
parameterize_3comp2 4.705 0.004 5.298
calc_clearance_frac 4.508 0.076 5.643
calc_elimination_rate 4.082 0.044 6.097
calc_vdist 4.072 0.008 7.365
calc_half_life 3.951 0.039 5.230
calc_hepatic_clearance 3.567 0.008 5.905
Flavor: r-devel-linux-x86_64-debian-clang
Version: 2.7.0
Check: examples
Result: ERROR
Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:
> ### Name: solve_dermal_pbtk
> ### Title: Solve_dermal_PBTK
> ### Aliases: solve_dermal_pbtk
> ### Keywords: Solve
>
> ### ** Examples
>
>
> # Dermal exposure to default dose
> out <- solve_dermal_pbtk(chem.name="bisphenola")
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
Vvehicle not specified, so set to 0.1 L.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
The initial.dose is automatically set to 1mg/kg.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment, :
Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Funbound.plasma recalculated with adjustment. Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species, :
Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
DLSODA- At T (=R1) and step size H (=R2), the
corrector convergence failed repeatedly
or with ABS(H) = HMIN
In above message, R1 = 0, R2 = 1e-08
Warning in lsoda(y, times, func, parms, ...) :
repeated convergence test failures on a step, but integration was successful - inaccurate Jacobian matrix?
Warning in lsoda(y, times, func, parms, ...) :
Returning early. Results are accurate, as far as they go
None of the monitored components undergo unit conversions (i.e. conversion factor of 1).
AUC is area under the plasma concentration curve in uM*days units with Rblood2plasma = 0.77.
The model outputs are provided in the following units:
umol: Avehicle, Aplasma, Ain, Aexhaled, Atubules, Ametabolized
uM: Cgut, Cliver, Cven, Clung, Cart, Crest, Ckidney, Cplasma, Cskin_exposed, Cskin_unexposed, Cvehicle
uM*days: AUC
> # Dermal exposure to 20 mg/L in 0.01 L of octanol with wash-off after 8 hours
> # Since skin permeability happens quickly for bisphenol A, let's only look at 3 days.
> dose.conc <- 2 #mg/L
> Vvehicle <- 0.01 #L
> initial.dose <- dose.conc*Vvehicle
> out <- solve_dermal_pbtk(chem.name="bisphenola", initial.dose=initial.dose,
+ input.units="mg", Vvehicle=0.01,
+ Kskin2vehicle="octanol", dose.duration=8,
+ dose.duration.units="hr", days=3)
Warning in solve_dermal_pbtk(chem.name = "bisphenola", initial.dose = initial.dose, :
If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola", initial.dose = initial.dose, :
Washoff occurs automatically if dose.duration is used.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment, :
Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Funbound.plasma recalculated with adjustment. Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species, :
Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
DLSODA- At current T (=R1), MXSTEP (=I1) steps
taken on this call before reaching TOUT
In above message, I1 = 5000
In above message, R1 = 0.000195284
Warning in lsoda(y, times, func, parms, ...) :
an excessive amount of work (> maxsteps ) was done, but integration was not successful - increase maxsteps
Warning in lsoda(y, times, func, parms, ...) :
Returning early. Results are accurate, as far as they go
Error in (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
Some of the requested variables to monitor (monitor.vars) are not in
the columns of the deSolve output object. These variables should
belong to either the states or outputs of the model.
Calls: solve_dermal_pbtk -> do.call -> <Anonymous>
Execution halted
Flavor: r-devel-linux-x86_64-fedora-clang
Version: 2.7.0
Check: examples
Result: ERROR
Running examples in ‘httk-Ex.R’ failed
The error most likely occurred in:
> base::assign(".ptime", proc.time(), pos = "CheckExEnv")
> ### Name: solve_dermal_pbtk
> ### Title: Solve_dermal_PBTK
> ### Aliases: solve_dermal_pbtk
> ### Keywords: Solve
>
> ### ** Examples
>
>
> # Dermal exposure to default dose
> out <- solve_dermal_pbtk(chem.name="bisphenola")
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
If route is not chosen, it is set to dermal by default.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
Vvehicle not specified, so set to 0.1 L.
Warning in solve_dermal_pbtk(chem.name = "bisphenola") :
The initial.dose is automatically set to 1mg/kg.
Warning in get_clint(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Clint is provided as a distribution.
Warning in apply_clint_adjustment(Clint.point, Fu_hep = Fu_hep, suppress.messages = suppress.messages) :
Clint adjusted for in vitro partitioning (Kilford, 2008), see calc_hep_fu.
Warning in get_fup(dtxsid = dtxsid, chem.name = chem.name, chem.cas = chem.cas, :
Fraction unbound is provided as a distribution.
Warning in apply_fup_adjustment(fup.point, fup.correction = fup.adjustment, :
Fup adjusted for in vivo lipid partitioning (Pearce, 2017), see calc_fup_correction.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Funbound.plasma recalculated with adjustment. Set adjusted.Funbound.plasma to FALSE to use original value.
Warning in available_rblood2plasma(chem.cas = chem.cas, species = species, :
Human in vivo measured Rblood2plasma used.
Warning in parameterize_dermal_pbtk(chem.name = "bisphenola", species = "Human", :
Since parameter Kvehicle2water is null, vehicle containing chemical is assumed to be water.
Warning in get_caco2(chem.cas = chem.cas, chem.name = chem.name, dtxsid = dtxsid, :
Default value of 1.6 used for Caco2 permeability.
DLSODA- At T (=R1), too much accuracy requested
for precision of machine.. See TOLSF (=R2)
In above message, R1 = 9.96383e-06, R2 = nan
Warning in lsoda(y, times, func, parms, ...) :
Excessive precision requested. scale up `rtol' and `atol' e.g by the factor 10
Warning in lsoda(y, times, func, parms, ...) :
Returning early. Results are accurate, as far as they go
Error in (function (chem.name = NULL, chem.cas = NULL, dtxsid = NULL, :
Some of the requested variables to monitor (monitor.vars) are not in
the columns of the deSolve output object. These variables should
belong to either the states or outputs of the model.
Calls: solve_dermal_pbtk -> do.call -> <Anonymous>
Execution halted
Examples with CPU (user + system) or elapsed time > 5s
user system elapsed
solve_1tri_pbtk 6.400 0.032 8.023
parameterize_steadystate 6.333 0.098 8.729
solve_1comp 5.359 0.075 6.065
parameterize_3comp2 4.595 0.018 6.515
calc_clearance_frac 4.158 0.063 5.083
parameterize_pfas1comp 4.133 0.067 5.036
calc_elimination_rate 4.013 0.032 5.960
calc_half_life 3.778 0.035 5.695
Flavor: r-release-linux-x86_64
Version: 2.7.0
Check: installed package size
Result: NOTE
installed size is 7.9Mb
sub-directories of 1Mb or more:
data 3.1Mb
doc 2.0Mb
help 1.4Mb
Flavors: r-oldrel-macos-arm64, r-oldrel-macos-x86_64, r-oldrel-windows-x86_64